The present paper reviews evidence on the effect of antidepressant treatments on dopamine
transmission. Chronic treatment with antidepressant drugs potentiates the behavioural
stimulant responses elicited by the stimulation of dopamine receptors, including reward-
related behaviours. Moreover, antidepressants affect dopamine release in several brain
areas. The reviewed literature is discussed in terms of the possible mechanisms underlying
antidepressant-induced supersensitivity to dopamine-mediated behavioural responses, and …